PAVIA Simulated granular layer activity. The response of a portion of the granular layer of the cerebellum cortex was reproduced in computer simulations. This multi-scale model reproduces the network response based on the integration of the input signal (spikes delivered by mossy fiber bundle) in 4000 granule cells and 27 Golgi cells. Each cell is able to faithfully reconstruct the electroresponsiveness of real cells by reproducing the conductance of individual ion channels and the activation of individual synaptic receptors.